This research investigates the complex interplay between these natural hazards and the structural response of reinforced concrete buildings. Through a meticulous analysis of four distinct structural configurations, this study offers valuable insights into the structural behavior of buildings subjected to seismic and tsunami forces. The study delves into key parameters that influence structural performance, including base shear, axial and shear forces in columns, bending moments, and storey displacement. Notably, the study identifies the columns at the forefront of structures as particularly vulnerable to tsunami impact, bearing the highest axial and shear forces. Furthermore, the presence or absence of infill walls in lower floors significantly influences the distribution of bending moments within buildings. In assessing inter-storey displacement, the study reveals that it is more pronounced below the tsunami inundation depth, demonstrating the distinct behavior of structures in response to tsunami forces.