This paper presents a review of the full-scale experimental studies of soil-structure interaction. It briefly reviews the early research on soil-structure interaction, starting from the 193 Os, the studies of the Hollywood Storage Building in the U.S. (the first structure in California where earthquake strong motion was recorded in 1933), selected research on soil-structure interaction and full-scale testing from the 1970s to present, and experimental work on large model tests. It also presents examples of full-scale tests in actual structures, and an analysis of the trends in full-scale experimental studies of soil-structure interaction via the number of published journal and conference papers. It is concluded that monitoring of earthquake response in and around buildings and comprehensive full-scale tests of structures are the best experimental methods for investigating scil-structure interaction, because they are most complete, the boundary conditions are satisfied exactly, and the problems related to scaling and similarity laws are eliminated.