The seismic response of the buildings resting on sloping ground is significantly different from the response of the buildings resting on the level topography due to arise of irregularities in both horizontal and vertical planes. The present study deals with computation of degree of irregularities in the form of irregularity indices as per the recommendations by previous researchers. Experimental and numerical studies have been carried out to explore the dynamic behaviour of five storey buildings resting on suitable slope adopted as per irregularity indices. Prototype five storey building has been scaled to construct a model by applying suitable scaling laws. The scaled building models are subjected to seismic excitations at resonant frequencies using shake table facility. A comparative study has been carried out between experiments and Numerical front. The outcome of the study indicates that setback – stepback building configuration is not vulnerable significantly to seismic activity.